Endocannabinoid System

S2E2 Into the Endocannabinoidome

In this episode we journey beyond Cannabis and the endocannabinoid system into the endocannabinoidome! The endocannabinoidome is a relatively new concept used to describe the vast hundreds of compounds involved in the functioning of endocannabinoids and cannabinoid receptors. Learn about how this concept of the endocannabinoidome was formed, what clinicians think about its discovery, and what we can expect from the future of endocannabinoidome research! Plus hear an often overlooked story about the origin of “the entourage effect” and how the concept has been redefined for popular culture.

Featuring a contribution from Raphael Mechoulam, PhD via email and relevant excerpts from behind-the-scenes episodes:

BTS #5 Ethan Russo, MD

BTS #31 The Doctors Knox

BTS #35 Vincenzo Di Marzo, PhD

Stay curious, and take it easy!

BTS #35 Vincenzo Di Marzo, PhD on the Endocannabinoid System and the Endocannabinoidome

In this behind-the-scenes episode we join renowned endocannabinoid researcher Dr. Vincenzo Di Marzo, who has been studying endocannabinoids since their discovery in the late 1980s and 1990s. Dr. Di Marzo, along with his colleagues, originally proposed the concept of the endocannabinoid system, the entourage effect, and the endocannabinoidome. Currently Dr. Di Marzo is working on studying the relationships between endocannabinoids and the gut microbiome to better understand how cannabinoids may affect health through the gut. In our conversation we discuss Dr. Di Marzo’s fascination with endocannabinoids, how he conceptualizes the endocannabinoidome, common misunderstandings about endocannabinoids, how the concept of the “entourage effect” has evolved away from its original intended meaning, where the future of Cannabis research may be heading, and much more.

This was a career highlight of mine to be able to talk to Vincenzo and I am honored to share this conversation with you. Enjoy!

BTS #31 The Doctors Knox on the Endocannabinoid System and Revolutionizing Healthcare

In this behind-the-scenes conversation we speak with The Doctors Knox, aka The Knox Docs, including Drs. Janice, David, Rachel, and Jessica Knox to talk all about the endocannabinoid system and how our understanding of the endocannabinoid system and the endocannabinoidome is revolutionizing healthcare.

This was our first interview with four people at the same time, so it was quite a different experience and allowed for some unique dynamics that I hope you enjoy.

You can learn more about The Doctors Knox at https://doctorsknox.com/

BTS #28 Jacqueline von Salm PhD on Cannabis Terpenes, Drugs From Nature, Chemical Ecology

In this behind-the-scenes episode we sit down with organic chemist Jackie von Salm PhD (@terp_queen_phd on Instagram), who was a recent winner of the ElSohly award given to outstanding researchers in the Cannabis space. Her team recently discovered the presence of a terpene common only among certain varieties of Cannabis, which is not tested for currently among most Cannabis testing labs and has largely been excluded from the discussion when talking about categorizing Cannabis varieties by chemical profile. We also discuss the process of discovering natural products suitable for drug development, how chemistry is interconnected with ecology and psychology, what she wants to see from future Cannabis research and much more!

Jackie is a co-founder and CSO of the company Psilera Bioscience which is dedicated to exploring the potential of psychoactive natural products to treat mental health disorders.

Learn more about Psilera Bioscience at www.psilera.com

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BTS #26 Dr. Genester Wilson-King on Cannabis and Hormones, Women’s Health, Inequities in Healthcare

In this behind-the-scenes episode we talk with Dr. Genester Wilson-King, a board certified OB/GYN, Cannabis clinician, and hormone expert. Our conversation spanned many topics including how cannabinoids and hormones interact with one another, how Cannabis affects women differently than men, how Cannabis affects women after menopause differently than women experiencing cyclical hormones, how Cannabis affects cis gender people different than trans gender people, how Cannabis affects fertility, Cannabis during pregnancy and breastfeeding and much more!

Learn more about Dr. Wilson-King here: https://www.victoryrejuvenationcenter.com/

Enjoy and stay curious!

BTS #20 Linda Klumpers PhD on Cannify, Cannabinoid Pharmacology, Cannabis for Pain

In this behind-the-scenes (BTS) episode we sit down with Dr. Linda Klumpers, a clinical pharmacologist that has been studying how Cannabis and cannabinoids affect the body. Our conversation covered a lot of topics including how cannabinoids affect the body, clinical evidence for the entourage effect, how Cannabis affects pain and sleep, misconceptions about Cannabis, differences between studying Cannabis in the Netherlands versus the United States, and more!

Besides the clinical cannabinoid research that she is involved with, Dr. Klumpers is also the mind behind Cannify, a quiz that helps connect people to peer-reviewed human clinical data about Cannabis. Learn more about Cannify by going to www.Cannify.us

BTS #19 Dr. Junella Chin on Medical Uses of Cannabis, Pediatric Use, Women’s Health

In this behind-the-scenes (BTS) episode we talk with Dr. Junella Chin, a physician that has specialized in Cannabis and cannabinoid medicine. Our conversation spanned a variety of topics including pediatric Cannabis use, how Cannabis interacts with sexual hormones like estrogen and testosterone, how people of different ethnicities respond differently to Cannabis, the state of cannabinoid education in the modern healthcare system, and more!

You can learn more about Dr. Junella Chin by visiting www.DrJuneChin.com

BTS #11 Jason Miller DACM on Chinese Medicine, Cannabis, Cancer

In this behind-the-scenes (BTS) episode we speak with Dr. Jason Miller, an expert in traditional Chinese medicine with a focus on the treatment of cancer. In this conversation we explore how Dr. Miller conceptualizes Cannabis in relation to other medicinal plants, historical uses of Cannabis in Chinese medicine, the promise and limitations of Cannabis as a medicine, his experience with Cannabis as a cancer treatment, bridging the worlds of eastern and western medicine, and much more!

Enjoy, and stay curious!

#07 Cannabidiol (CBD): Hype or Hero?

Episode Description: In this episode of the Curious About Cannabis Podcast, we take a look at CBD, the cannabinoid that has been all the rage lately. We are joined by neurologist and cannabinoid researcher, Dr. Ethan Russo, anesthesiologist and pain physician, Dr. James Taylor, and co-owner of Artemis, a premier CBD shop in New York City, Wendy Nguyen, to discuss the history of CBD, what people are experiencing with CBD, and how CBD affects the body.

Look for the associated behind-the-scenes (BTS) episodes for each of our guests to hear our full conversations!

BTS #07 Dr. James Taylor on Chronic Pain and How CBD Inspired a Transformation in The Waiting Room

In this behind-the-scenes (BTS) episode, we talk with Dr. James Taylor, an anesthesiologist and pain physician working in North Carolina. Since the Farm Bill passed, his patients began trying CBD products to treat their chronic pain. What Dr. Taylor witnessed next could be described as nothing short of transformative – but perhaps not in the way you’d think. Now Dr. Taylor has started a company called Integrated Hemp Solutions to bring physician-developed, clinically tested hemp based products to the public.

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