CBD and the CB1 Receptor: A Look at Allosteric Modulation with Rob Laprairie, PhD + Liz Thompson, MS | #102
By cacpodcast.comHow does CBD affect the CB1 receptor, really?
Rob Laprairie is a cannabinoid researcher out of the University of Saskatchewan who was involved in the discovery of CBD’s allosteric binding activity on the CB1 receptor – leading to a host of speculative theories about how CBD influences the activity of THC. In this conversation, continuing our Train with Mary Jane series, we sit down with Rob and discuss his work studying the CB1 receptor to better understand how CBD and “minor” cannabinoids from Cannabis affect the body. Rob helps break down common misunderstandings about CBD’s effects, explains how our understanding of chemical receptors is evolving, and what the future of cannabinoid research may look like.
“Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors”: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14440
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HHC, THCP, and Beyond with Westley Cruces of Colorado Chromatography
You may have noticed that your local gas station has started selling products marketed like Cannabis products with promises that they are legal ways to get you high without THC. No, we haven’t gone back in time. This isn’t 1999 and no, you’re not reading one of those “legal bud” ads in the back of the High Times magazine. This is 2024 and we are seeing a re-emergence of synthetic cannabinoids, particularly THC analogues, now presumably legal under the guise of the 2018 Farm Bill.
Colorado Chromatography is one of the leading labs responsible for producing and studying these new cannabinoids on the block, like HHC, H4CBD, THCP, and others. In this conversation we sit down with the Chief Science Officer of and co-founder of Colorado Chromatography, Westley Cruces, to talk about their journey learning about these molecules, the results from preliminary safety studies on HHC, evidence of fraud in delta-8 and THCP products, and more!
Learn more about Colorado Chromatography: https://coloradochromatography.com/
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Is Acetone Lurking in Your Terpenes? and Other Cannabis Science Musings feat. Jeff Raber, PhD
We kick off 2024 catching up with Dr. Jeff Raber of The Werc Shop to talk about Cannabis quality, Cannabis potency testing fraud, THC inflation, acetone showing up in Cannabis extracts, preparing young scientists for working in the Cannabis industry, the launch of The Werc Shop’s ENTOUR brand and more!
How do we fix the lab testing fraud issue in the Cannabis industry?
Why is acetone showing up in terpene-rich Cannabis samples?
How can young scientists prepare for the brutal realities of working for a startup Cannabis company?
We explore these questions and more in this episode of The Curious About Cannabis Podcast!
Learn more about ENTOUR at www.entourbrand.com
Learn more about The Werc Shop at www.thewercshop.com
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Looking Back on Cannabis Research from 2023 | BTS 96
Welcome back! In this episode we will spend some time diving into some of the top several scientific research articles about Cannabis that got my attention in 2023. Also, don’t forget to sign up for the 2024 Curious About Cannabis Master Class before we fill up! As of now we have 7 spots left before we are all full for the year. Don’t miss your chance to attend one of the most epic and rewarding Cannabis education events of the year!
Articles mentioned:
Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic Cannabis – https://pubs.acs.org/doi/full/10.1021/acsomega.3c04496
Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation – https://www.sciencedirect.com/science/article/pii/S0006295223001399
Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model – https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282920
Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders – https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.3c00599
Cannabis: a multifaceted plant with endless potentials – https://www.frontiersin.org/articles/10.3389/fphar.2023.1200269/full
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The Science Behind CBG: A Pharmacist’s Perspective with Codi Peterson PharmD MS
Explore the fascinating world of Cannabigerol (CBG) in the latest episode of our podcast! We are joined by our friendly neighborhood pharmacist – Dr. Codi Peterson. As we delve into the hot topic of CBG, we cover its effects on the body and compare it to other medications. We also take an unexpected detour to discuss the influence of AI like ChatGPT in Cannabis education. Join us as we ponder the future of Cannabis content, engage in lively conversation, and learn a lot more about this promising cannabinoid. Tune in now!
#CBG #CannabisCommunity #Cannabinoids #HempProducts #PharmacyInsights #CannabisEducation #ChatGPT #FutureOfCannabisContent #CannabisPodcast #CuriousAboutCannabis #CodiPeterson #JasonWilsonMS #HempScience #Cannabigerol #CannabisIndustry #CannabisCommunity
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Remembering Raphael Mechoulam’s Legacy on Cannabis Science with Mark Scialdone, PhD | BTS 91
In this special episode we get together with chemist and Cannabis science educator Mark Scialdone, PhD to talk about the passing of “the godfather of Cannabis science”, Raphael Mechoulam, PhD. After his passing, many media and news outlets failed to accurately portray Mechoulam’s contributions or his place in the grand story of Cannabis science – so Dr. Scialdone and I decided to try to do our part to set the record straight. Along the way we spin off into talking about a variety of other topics like delta-8-THC synthesis from CBD, common misunderstandings around Cannabis chemistry, why the boiling point of THC is almost always incorrectly reported, and more.
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The Quest for the CB3 Receptor and Beyond with Viola Brugnatelli, PhD | BTS 89
Is there a CB3 receptor?
In this episode we catch up with Italian endocannabinoid system researcher and neuropharmacologist Viola Brugnatelli, PhD to discuss her work investigating the activity of orphaned G-protein coupled receptors (GPCRs) like GPR55, GPR18, GPR92, and others.
We also discuss Viola’s decision to focus her energy on educating the healthcare community and others about the science of Cannabis through her company Cannabiscientia which just published a great resource for health care providers called The Principles of Clinical Cannabinology.
To learn more about Cannabiscientia, visit https://cannabiscientia.com/
#cannabis #cannabinoids #cb3 #ecs #endocannabinoidsystem #cannabiscientia #cannabisscience #cannabinoidpharmacology #medicalcannabis #medicalmarijuana #curiousaboutcannabis
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Cannabis and the Convergence of Neurodivergence with Miyabe Shields PhD | BTS 87
Disclaimer: In this episode, we discuss some heavy topics that touch on mental health struggles and suicidal ideation. None of the information in this episode or any other Curious About Cannabis episode should be considered medical advice. All of our content is for educational and entertainment purposes only.
In this raw behind-the-scenes episode I had the chance to catch up with endocannabinoid system researcher and science communicator Miyabe Shields, PhD. We spent much of our time together discussing the convergence of Cannabis, mental health, and neurodivergence – addressing many of the taboos and social stigmas associated with altering consciousness and treating the mind with Cannabis.
This is almost certainly just the beginning of a series of conversations that Miyabe and I will be having as we continue to unpack their fascination with the endocannabinoid system and natural products science – so stay tuned for more!
#Cannabis #CannabisResearch #Neurodiversity #Neurodivergent #Spectrum #Consciousness #CannabisEducation #MedicalCannabis #CannabisForMentalHealth #Psychology #NaturalProducts #CuriousAboutCannabis
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Unraveling the DNA of Cannabis with Oussama Badad of Trilogene Seeds | BTS 82
In this behind-the-scenes episode I chat with Oussama Badad, the lead geneticist for Trilogene Seeds to talk about the science behind Cannabis genetics and gene editing technologies. We discuss common misconceptions around gene editing, how gene editing using tools like CRISPR and RNA interference is different than the genetic modification technologies used to produce GMOs, how gene edited Cannabis plants could affect the Cannabis industry, Trilogene Seeds’ quest to produce THC-free hemp plants, Cannabis tissue culturing, and much more.
Learn more about Trilogene Seeds at trilogeneseeds.com
#CannabisEducation #CannabisGenetics #Cannabis #Hemp #THCFree #CannabisPodcast #CuriousAboutCannabis
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Cannabinoid Science: Past, Present and Future (Southern Oregon University Lecture, 2021)
The history of cannabinoid science tells a fascinating story that many people are really unfamiliar with. In this lecture, which I gave for Southern Oregon University back in October of 2021, I chart some of the basic series of events that led to the discovery of CBD, THC, cannabinoid receptors, the endocannabinoid system, and the endocannabinoidome.
The video associated with this lecture is available on the Curious About Cannabis YouTube at http://www.youtube.com/@curiousaboutcannabis
The 2023 Curious About Cannabis Master Class is coming up! Spend 6 months diving into a Cannabis science crash course with me and over a dozen special guests! Register today at http://www.masterclasscannabis.com
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