Episodes
CBD and the CB1 Receptor: A Look at Allosteric Modulation with Rob Laprairie, PhD + Liz Thompson, MS | #102
By cacpodcast.comHow does CBD affect the CB1 receptor, really?
Rob Laprairie is a cannabinoid researcher out of the University of Saskatchewan who was involved in the discovery of CBD’s allosteric binding activity on the CB1 receptor – leading to a host of speculative theories about how CBD influences the activity of THC. In this conversation, continuing our Train with Mary Jane series, we sit down with Rob and discuss his work studying the CB1 receptor to better understand how CBD and “minor” cannabinoids from Cannabis affect the body. Rob helps break down common misunderstandings about CBD’s effects, explains how our understanding of chemical receptors is evolving, and what the future of cannabinoid research may look like.
“Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors”: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14440
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Hidden Threats: Exploring Viruses and Viroids with IPM Specialist Matthew Gates | #101
In this episode we sit down with Integrated Pest Management (IPM) specialist Matthew Gates to delve into the often-overlooked world of cannabis viruses and viroids. In this episode, Matthew brings his extensive expertise to the table, shedding light on the insidious pathogens that can silently wreak havoc on cannabis crops.
As the cannabis industry continues to grow and evolve, understanding the hidden threats posed by viruses and viroids becomes paramount. Matthew explains the various types of viruses and viroids that can affect cannabis plants, their symptoms, and the potential economic impact on growers. He also shares insights into the latest research and diagnostic techniques that can help detect these pathogens early, enabling proactive management and prevention.
But it’s not all doom and gloom. Matthew provides practical, actionable advice on how to implement effective IPM strategies to mitigate the risks. From cultural practices to biological controls and cutting-edge technologies, he covers a comprehensive range of tools and methods that can help protect your cannabis crop and ensure its health and productivity.
Whether you’re a seasoned cultivator, a novice grower, or simply interested in the science behind cannabis cultivation, this episode is packed with valuable information that you won’t want to miss. Tune in to gain a deeper understanding of the challenges posed by cannabis viruses and viroids and learn how to safeguard your plants against these unseen adversaries.
Learn more about Matthew at www.zenthanol.com
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Concussions and the Endocannabinoid System with Patrick Neary, PhD and Liz Thompson, PhDc, MSc | #100
Dive into a journey of discovery with our latest episode of the ‘Train With Mary Jane’ mini-series, where we delve deep into the pioneering research funded by the NFL on Cannabis and its potential to revolutionize the treatment of traumatic brain injuries (TBIs) in athletes. This episode welcomes the return of clinical physiologist Liz Thompson and introduces a new, distinguished guest, Dr. Patrick Neary, PhD – a researcher in the realm of kinesiology from the University of Regina, Canada, with a passion for unraveling the mysteries of concussions and TBIs.
Join us as we embark on an exploration of Dr. Neary’s experience in concussion research, unlocking the intricate science behind concussions, the profound long-term effects of TBIs, and the promising intersection of TBI treatment with the endocannabinoid system. Discover the potential of cannabinoids in altering the landscape of TBI therapy and much more!
For those eager to learn more about the ‘Train with Mary Jane’ initiative and the NFL’s foray into cannabis research for athlete care, visit Mary Jane Athletics or Train with Mary Jane. Don’t miss this captivating episode that bridges the worlds of sports, science, and hope through the lens of cannabis research.
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BONUS: Will Insurance Companies Ever Cover Cannabis Expenses? with Liz Thompson PhDc, MSc
After our initial episode concluded with Liz Thompson, we decided we had more to talk about so we hit record! Enjoy this bonus conversation where we explore how Canada handles insurance coverage for Cannabis expenses and what the future of health insurance coverage for Cannabis could look like in Canada and the US.
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Train with Mary Jane: Inside the NFL’s Quest to Research Cannabinoids for Athletic Injury with Liz Thompson PhDc, MSc | #99
Elizabeth Thompson is a researcher at the University of Saskatchewan currently working on a project that has started to get international attention – the National Football League’s (NFL) million dollar research project to understand how cannabinoids could impact the health and safety of athletes. In this behind-the-scenes conversation we hear Liz’s story about her personal connection to professional sports, her journey to understand molecular mechanisms of the body, links between the endocannabinoid system and sports injury recovery, and how a moment of inspiration snowballed into the clinical trial now titled “Cannabinoids for Pain Management and Neuroprotection From Concussion” (ClinicalTrials.gov ID: NCT06204003).
If you are an athlete, athletic trainer or sports healthcare worker, you have an opportunity to contribute to the NFL research project! Visit www.maryjaneathletics.com to complete a survey so that your experience and voice can be represented in this groundbreaking project!
Learn more at:
https://www.maryjaneathletics.com/
https://clinicaltrials.gov/study/NCT06204003
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HHC, THCP, and Beyond with Westley Cruces of Colorado Chromatography
You may have noticed that your local gas station has started selling products marketed like Cannabis products with promises that they are legal ways to get you high without THC. No, we haven’t gone back in time. This isn’t 1999 and no, you’re not reading one of those “legal bud” ads in the back of the High Times magazine. This is 2024 and we are seeing a re-emergence of synthetic cannabinoids, particularly THC analogues, now presumably legal under the guise of the 2018 Farm Bill.
Colorado Chromatography is one of the leading labs responsible for producing and studying these new cannabinoids on the block, like HHC, H4CBD, THCP, and others. In this conversation we sit down with the Chief Science Officer of and co-founder of Colorado Chromatography, Westley Cruces, to talk about their journey learning about these molecules, the results from preliminary safety studies on HHC, evidence of fraud in delta-8 and THCP products, and more!
Learn more about Colorado Chromatography: https://coloradochromatography.com/
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Is Acetone Lurking in Your Terpenes? and Other Cannabis Science Musings feat. Jeff Raber, PhD
We kick off 2024 catching up with Dr. Jeff Raber of The Werc Shop to talk about Cannabis quality, Cannabis potency testing fraud, THC inflation, acetone showing up in Cannabis extracts, preparing young scientists for working in the Cannabis industry, the launch of The Werc Shop’s ENTOUR brand and more!
How do we fix the lab testing fraud issue in the Cannabis industry?
Why is acetone showing up in terpene-rich Cannabis samples?
How can young scientists prepare for the brutal realities of working for a startup Cannabis company?
We explore these questions and more in this episode of The Curious About Cannabis Podcast!
Learn more about ENTOUR at www.entourbrand.com
Learn more about The Werc Shop at www.thewercshop.com
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Looking Back on Cannabis Research from 2023 | BTS 96
Welcome back! In this episode we will spend some time diving into some of the top several scientific research articles about Cannabis that got my attention in 2023. Also, don’t forget to sign up for the 2024 Curious About Cannabis Master Class before we fill up! As of now we have 7 spots left before we are all full for the year. Don’t miss your chance to attend one of the most epic and rewarding Cannabis education events of the year!
Articles mentioned:
Minor, Nonterpenoid Volatile Compounds Drive the Aroma Differences of Exotic Cannabis – https://pubs.acs.org/doi/full/10.1021/acsomega.3c04496
Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation – https://www.sciencedirect.com/science/article/pii/S0006295223001399
Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model – https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282920
Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders – https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.3c00599
Cannabis: a multifaceted plant with endless potentials – https://www.frontiersin.org/articles/10.3389/fphar.2023.1200269/full
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EPIC 2024 Master Class, Book Discounts, Equipment Upgrades, and More Updates!
What’s going on with Curious About Cannabis? Lots! Tune in to learn about the updates.
Go to http://www.masterclasscannabis.com to sign up for the 2024 Curious About Cannabis Master Class
Visit http://member.cacpodcast.com/ to join the Curious About Cannabis membership platform and get access to courses, videos, every podcast episode including unreleased episodes, and more!
Use code “cachalloween” for 20% off CAC books until they are gone! Visit http://store.cacpodcast.com to shop now.
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Cannabis – A Case of Cultonomic Neglect with Trevor Wittke | BTS 95
Did our modern conception of “sativa”, “indica”, and “ruderalis” come about because of politics rather than science? What have been the political and social factors influencing how scientists have studied and discussed Cannabis?
I had the opportunity to meet Trevor Wittke to talk all about these issues and more. Trevor is a Cannabis breeder and lifelong curious mind who spends much of his time diving into the sometimes lost and opaque history of Cannabis science to better understand the plant and share his findings with others.
In this discussion we unpack his recent exploration into 20th century debates around Cannabis taxonomy, particular between Richard Schultes and Ernest Small. We also talk about the strain debate and what we can learn from reading the International Code of Nomenclature for Cultivated Plants. We also spend time exploring key issues and concepts critical for breeders to study and understand in order to improve the landscape of commercial Cannabis.
If you grow Cannabis or are interested in the history of Cannabis, you will not want to miss this episode!
#CuriousAboutCannabis #CannabisEducation #Hemp #CannabisCommunity #CannabisIndustry #HempEducation #CannabisTaxonomy #Strains #Cultivar #Chemovar #Cultigen #ICNCP #UPOV #CannabisBreeding #CannabisCultivation #HempCultivation #HempBreeding
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Curious About Cannabis is a learning initiative by Natural Learning Enterprises dedicated to promoting scientific literacy and critical thinking about Cannabis, cannabinoids and the endocannabinoid system.
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