Entourage Effect

Kevin Spelman PhD on Herbs to Compliment or Counteract Cannabis Effects | BTS #64

In this behind-the-scenes conversation we meet up again with molecular biologist Kevin Spelman, PhD to talk about medicinal herbs that can either compliment or counteract the effects of Cannabis in different ways. Along the way we spin out into all sorts of other topics like discussing “adaptogens”, allostatic vs. homeostatic systems in the body, issues around placebo effects and Cannabis, potential dangers concerning inhaling high concentrations of terpenes, thinking critically about drug-drug interactions with Cannabis, and more!

Learn more about Dr. Spelman’s show The Spelman Report: Phytopharmacology Review at www.thespelmanreport.com

Check out Dr. Spelman’s prior appearance on the show in Curious About Cannabis Behind-the-Scenes Episode #4: https://cacpodcast.com/bts-04-kevin-spelman-phd-on-the-endocannabinoid-system-plant-synergies-and-dietary-supplement-research/

Stay curious, and take it easy!

Codi Peterson PharmD on the Endocannabinoidome and Common Drugs, Preserving Cannabis as Medicine | BTS #63

In this behind-the-scenes episode we are joined with pharmacist Dr. Codi Peterson to talk about how modern insights into the endocannabinoid system and endocannabinoidome are affecting how pharmacists think about modern medicine.

Dr. Codi Peterson is a clinical pediatric pharmacist with diverse experiences across the pharmaceutical landscape. A Duquesne University graduate, Codi was trained in an academic teaching hospital where he learned alongside a team of healthcare professionals. Building upon general pediatric hospital experience, Codi advanced to emergency and critical care pharmacy where he found a passion for improving the pharmaceutical care of complex and dynamic patients.

Leveraging his hospital experience, Codi has had the opportunity to pursue his passion for educating others. As a staff lecturer at Orange County Emergency Medical Training, Codi teaches paramedics and firefighters the knowledge and skills they need to employ safe drug therapy in the prehospital setting. Codi has an innate ability to translate complex pharmacological information into digestible concepts that are applicable in the field. Codi also lectures to respiratory therapists and pharmacy students in the SoCal area, sharing his knowledge at every possible occasion.

Now turning his focus and skills from western medicine to a more functional and holistic therapeutic approach, Codi is enrolled at the University of Maryland School of Pharmacy where he is obtaining his MS in Medical Cannabis Science & Therapeutics. He is the President of the Medical Cannabis Student Association at UMB, an active member of the International Society of Cannabis Pharmacists, as well as the Association of Cannabinoid Specialists. With his extensive pediatric experience, Codi is poised to bring a new and needed perspective to the cannabis space. While a proponent of individual rights, home grow, and global cannabis reform, Codi also aims to defend the sanctity of medical cannabis. Codi believes cannabis IS medicine, that all patients deserve access to medicine, and that includes access to trained healthcare professionals who are able to manage complex medical patients.

You can learn more about Codi’s work in Cannabis by visiting: http://pharmdapproved.com/

Stay curious, and take it easy!

BTS #62 Ethan Russo MD on a New Understanding of Cannabinoid Hyperemesis Syndrome

In this behind-the-scenes conversation, we are joined once again by cannabinoid researcher Dr. Ethan Russo. Russo and a team of researchers recently published a research paper entitled, “Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation” which announced findings that could help explain the physiology of CHS, provide tools for screening Cannabis users for CHS, and lead to the development of targeted treatments for CHS.

Throughout our conversation Dr. Russo explains what CHS is, how it compares to Cyclical Vomiting Syndrome, common misunderstandings about CHS, the results of his recent research study, and what we might expect from the future of CHS research.

Read the study: https://pubmed.ncbi.nlm.nih.gov/34227878/

Learn more about CReDO Science: www.credo-science.com

Stay curious!

BTS #60 Linda Klumpers PhD on Rimonabant, CB1 Antagonists, Role of CB2

In this behind-the-scenes episode we are joined once again by Dr. Linda Klumpers, a clinical pharmacologist that has been spending her professional career understanding how cannabinoids and cannabinoid receptors work in the body.

We spend this episode discussing the concept of CB1 receptor antagonists and the story of a hopeful drug from the 1990s, Rimonabant, that ended up teaching researchers a painful lesson about cannabinoid receptor pharmacology. We also discuss our limited understanding of CB2 receptors, the future of cannabinoid receptor antagonist drugs, and more!

Want to learn more about cannabinoid pharmacology? Dr. Klumpers and the team at Cannify has teamed up with Curious About Cannabis to produce a series of cannabinoid pharmacology courses and lecture videos available at the Curious About Cannabis Learning Center at www.cannabis-courses.com. Check out our Cannabinoid Pharmacology Basics course today and get 15% off with discount code “cacxcannify”

BTS #47 Tanja Bagar, PhD on Medical Cannabis in Europe, ECS Fascinations, International Collaboration

In this behind-the-scenes conversation we are joined by Tanja Bagar, PhD, the founder and CEO of the International Institute for Cannabinoids, a multi-national research and education cooperative based out of Slovenia. Tanja holds a PhD in Biomedical Sciences and has spent the past several years focused on studying and teaching about cannabinoids throughout Europe. Tanja and I have been collaborating for years as co-authors on conference abstracts, book chapters, etc. Tanja was also one of my early students in the early iterations of my workshop series which I still teach today, so it was great to reconnect on the podcast.

Our conversation explored her experience discovering the therapeutic potential of cannabinoids, how Cannabis regulations vary throughout Europe and the effects that has on research collaboration, why she has become fascinated with the endocannabinoid system, clinical outcomes that ICANNA and their collaborators have seen in patients using cannabinoids, her thoughts about the future of Cannabis research, and much more!

You can learn more about ICANNA by visiting https://www.institut-icanna.com/en/index.html

BTS #44 Janna Champagne RN on Cannabis Inclusive Autism Care Resources

In this behind-the-scenes conversation we are joined by another returning guest, Cannabis nurse Janna Champagne. Nurse Janna recently founded Autism Safe Haven, a nonprofit focused on making Cannabis inclusive autism care services available wherever medical Cannabis is legal. In this conversation we focus on the intersection between Cannabis and autism, why current autism care models are often ineffective, how cannabinoids may affect autism symptoms, and more!

Learn more about Autism Safe Haven at www.autismsafehaven.org

S2E2 Into the Endocannabinoidome

In this episode we journey beyond Cannabis and the endocannabinoid system into the endocannabinoidome! The endocannabinoidome is a relatively new concept used to describe the vast hundreds of compounds involved in the functioning of endocannabinoids and cannabinoid receptors. Learn about how this concept of the endocannabinoidome was formed, what clinicians think about its discovery, and what we can expect from the future of endocannabinoidome research! Plus hear an often overlooked story about the origin of “the entourage effect” and how the concept has been redefined for popular culture.

Featuring a contribution from Raphael Mechoulam, PhD via email and relevant excerpts from behind-the-scenes episodes:

BTS #5 Ethan Russo, MD

BTS #31 The Doctors Knox

BTS #35 Vincenzo Di Marzo, PhD

Stay curious, and take it easy!

BTS #35 Vincenzo Di Marzo, PhD on the Endocannabinoid System and the Endocannabinoidome

In this behind-the-scenes episode we join renowned endocannabinoid researcher Dr. Vincenzo Di Marzo, who has been studying endocannabinoids since their discovery in the late 1980s and 1990s. Dr. Di Marzo, along with his colleagues, originally proposed the concept of the endocannabinoid system, the entourage effect, and the endocannabinoidome. Currently Dr. Di Marzo is working on studying the relationships between endocannabinoids and the gut microbiome to better understand how cannabinoids may affect health through the gut. In our conversation we discuss Dr. Di Marzo’s fascination with endocannabinoids, how he conceptualizes the endocannabinoidome, common misunderstandings about endocannabinoids, how the concept of the “entourage effect” has evolved away from its original intended meaning, where the future of Cannabis research may be heading, and much more.

This was a career highlight of mine to be able to talk to Vincenzo and I am honored to share this conversation with you. Enjoy!

BTS #31 The Doctors Knox on the Endocannabinoid System and Revolutionizing Healthcare

In this behind-the-scenes conversation we speak with The Doctors Knox, aka The Knox Docs, including Drs. Janice, David, Rachel, and Jessica Knox to talk all about the endocannabinoid system and how our understanding of the endocannabinoid system and the endocannabinoidome is revolutionizing healthcare.

This was our first interview with four people at the same time, so it was quite a different experience and allowed for some unique dynamics that I hope you enjoy.

You can learn more about The Doctors Knox at https://doctorsknox.com/

BTS #28 Jacqueline von Salm PhD on Cannabis Terpenes, Drugs From Nature, Chemical Ecology

In this behind-the-scenes episode we sit down with organic chemist Jackie von Salm PhD (@terp_queen_phd on Instagram), who was a recent winner of the ElSohly award given to outstanding researchers in the Cannabis space. Her team recently discovered the presence of a terpene common only among certain varieties of Cannabis, which is not tested for currently among most Cannabis testing labs and has largely been excluded from the discussion when talking about categorizing Cannabis varieties by chemical profile. We also discuss the process of discovering natural products suitable for drug development, how chemistry is interconnected with ecology and psychology, what she wants to see from future Cannabis research and much more!

Jackie is a co-founder and CSO of the company Psilera Bioscience which is dedicated to exploring the potential of psychoactive natural products to treat mental health disorders.

Learn more about Psilera Bioscience at www.psilera.com

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