Cannabis Chemistry

BTS #62 Ethan Russo MD on a New Understanding of Cannabinoid Hyperemesis Syndrome

In this behind-the-scenes conversation, we are joined once again by cannabinoid researcher Dr. Ethan Russo. Russo and a team of researchers recently published a research paper entitled, “Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation” which announced findings that could help explain the physiology of CHS, provide tools for screening Cannabis users for CHS, and lead to the development of targeted treatments for CHS.

Throughout our conversation Dr. Russo explains what CHS is, how it compares to Cyclical Vomiting Syndrome, common misunderstandings about CHS, the results of his recent research study, and what we might expect from the future of CHS research.

Read the study: https://pubmed.ncbi.nlm.nih.gov/34227878/

Learn more about CReDO Science: www.credo-science.com

Stay curious!

BTS #61 Markus Roggen PhD on Optimizing Cannabis Extraction and Research

In this behind-the-scenes episode we sit down with chemist Dr. Markus Roggen of Delic Labs (formerly Complex Biotech Discovery Ventures) to talk about his journey to help Cannabis processors and researchers optimize their processes, make better products and uncover better data about Cannabis and cannabinoids.

Throughout the conversation we talk about his journey coming from Germany to California and what it was like getting involved in Cannabis research. We also discuss many of the different research projects that he has been involved in and the insights that he and his teams have been able to gain about extraction science and cannabinoid chemistry. Finally we discuss some of the work that Delic Labs is doing with psychedelics and what they hope to uncover about nature’s mind manifesting molecules.

You can learn more about Delic Labs at: https://deliclabs.com/

Stay curious and take it easy!

BTS #54 Jonathan Mintle aka Botanichemist on Solventless Hash and Rosin Making

In this behind-the-scenes conversation we join Jonathan Mintle, aka Botanichemist, to talk about solventless Cannabis extracts. We spent nearly 3 hours going over every bit of nuance that someone might need to understand if they intend on getting into solventless hash or rosin production. We discuss important considerations that affect final product quality, how to evaluate Cannabis resin trichomes in the context of hashmaking, why different sized micron filters matter in hash production, what it takes to make high quality rosin, and a lot more!

This 3 hour conversation was cut for time. Hear the whole conversation at www.patreon.com/CuriousAboutCannabis

Learn more about Botanichemist Consulting at http://botanichemist.com

Hope you enjoy! Stay curious and take it easy!

BTS #43 Murphy Murri (Returns!) on CRC, Color in Extracts, Concentrate Remediation

In this behind-the-scenes conversation we are rejoined with extraction technologist and Cannabis educator Murphy Murri to talk all about CRC aka “Color Remediation Cartridges”. CRC has gained a lot of buzz, both positive and negative, in recent years as extractors experiment with refinement techniques that manipulate the appearance of the extract. The concept of “colorless” Cannabis extracts was largely popularized by The Clear years ago, and now has become commonplace. But what is CRC? And what is happening to these extracts when their color is “remediated”? And does CRC present any risks to consumers or extraction technicians?

Murphy Murri provides a common sense take on CRC for anyone wanting to wrap their minds around this popular topic.

BTS #39 Arno Hazekamp PhD on Cannabis Chemovars, Controversies, and the Need for Better Education

In this behind-the-scenes interview we are joined by Arno Hazekamp, PhD. Arno is based out of the Netherlands and has been researching Cannabis since 2001. He is probably most famous for proposing the concept of Cannabis chemovars to replace the idea of “strains”. His work has primarily focused on examining the chemical constituents of Cannabis and Cannabis products including Cannabis teas, Rick Simpson Oil (RSO), and more. He has also published numerous papers on other topics like Cannabis sterilization via gamma irradiation, review papers on human clinical research around Cannabis, and many more.

Arno shares my passion for science communication and science education, which came through very clearly in this conversation. We discussed many different topics over the course of the two hours including common Cannabis misconceptions, evidence for therapeutic applications of Cannabis, how to think about “strains” and indica/sativa vernacular, the best way to make Cannabis tea, the importance of writing scientific papers with a lay audience in mind, and a whole lot more!

Connecting with Arno was a delight and I look forward to talking to him again in the future. I hope you enjoy this conversation as much as I did.

Learn more about Arno’s work at https://hazekamp.info/

BTS #38 Jeffrey Raber PhD on The Werc Shop, Cannabis Testing, Delta-8 THC Impurities, Product Standardization

In this behind-the-scenes episode we talk with Dr. Jeff Raber of The Werc Shop, a Cannabis and cannabinoid science and technology company that began testing Cannabis products in California back in 2010. Our conversation explores Dr. Raber’s background in biochemistry, the turbulent history of Cannabis testing labs, how Cannabis companies began leveraging Cannabis test results to improve products, impurities found in delta-8 THC products, the future of The Werc Shop and more!

Learn more about The Werc Shop: https://thewercshop.com/

The Curious About Cannabis Podcast is produced by Natural Learning Enterprises, a mission driven company focused on enhancing critical thinking skills and public scientific literacy about life and the natural world. If you enjoy Curious About Cannabis, consider checking out some of these other programs by Natural Learning Enterprises:

Learn more about Natural Learning Enterprises at www.NaturalEDU.com

BTS #37 Marcus “Bubbleman” Richardson on Bubble Hash, Legacy in Cannabis, Defense of Isolates

In this behind-the-scenes episode we join Cannabis culture icon Marcus “Bubbleman” Richardson. In the mid 1990s, he was one of the first to receive an industrial hemp license in Canada and began performing research and development with hemp varieties of Cannabis very early in his career. Marcus is also the producer of “bubble bags” and popularized bubble hash in the late 1990s and early 2000s. In 2014 he started a weekly long-form Cannabis show called Hash Church, which had a huge influence on Cannabis culture and the development of Cannabis extraction technology. Marcus is also a photographer and has an extensive library of macro photos of Cannabis trichomes and other curious odds and ends.

In our conversation we talked about the science of hash making, Marcus’ legacy in the Cannabis industry, lessons he has learned, the battle between full spectrum and cannabinoid isolates, and much more!

Learn more about Marcus’ work at www.bubblemanbrand.com

BTS #36 Anna Schwabe PhD on Sources of Variation in Cannabis Plants, Hope for Indica/Sativa?

In this behind-the-scenes episode we join Anna Schwabe, PhD, a geneticist and plant scientist that spent her PhD work examining how and why Cannabis plants exhibit different chemical profiles, smells, and effects. In our conversation we dive into many of these nuances and talk about whether people can distinguish Cannabis varieties consistently by smell, how much variation exists between Cannabis plants labeled as the same strain, and whether there may be some hope after all for the colloquial use of the terms “indica” and “sativa”.

Learn more about Anna’s work at www.annaschwabe.com

BTS #32 Mark Scialdone PhD on Cannabis Chemistry History, Hydrogenated Cannabinoids, Science and Art

In this behind-the-scenes episode we sit down with Mark Scialdone PhD, a chemist responsible for inventing hydrogenated cannabinoid acids, semi-synthetic cannabinoids that could be effective at battling certain types of cancer. We discuss the history of cannabinoid science, controversy around cannabinoid boiling points, how Mark learned from his research with catnip essential oil hydrogenation and how he adapted the technology for Cannabis essential oil, the importance of balancing science with art, the future of Cannabis research, his role in helping the American Chemical Society’s Cannabis Chemistry subdivision get started, and much more.

This episode was cut for time. To listen to the extended 2+ hour version, visit www.Patreon.com/CuriousAboutCannabis

BTS #29 Kyle Boyar on Microbiological Testing, Cannabinoid Hyperemesis Syndrome, LIMS

In this behind-the-scenes episode we sit down with Kyle Boyar, vice chair and scholarship chair for the Cannabis Chemistry subdivision of the American Chemical Society and Director of Product Science at TagLeaf. We talked about the ways Cannabis testing labs test Cannabis samples for microbiological contaminants, how microbiological testing can go wrong, other issues facing Cannabis testing, controversy around a medical condition called Cannabinoid Hyperemesis Syndrome (CHS), and more!

This conversation was cut to fit our new 1.5 hour limit. To listen to the entire 2 hour conversation, join our community on Patreon at www.Patreon.com/CuriousAboutCannabis

Enjoy and stay curious!

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