Cannabis Chemistry

How Do Testing Labs Boost THC Numbers? | Lecture by Jason Wilson MS

45% THC Flower?!

It is a well known issue in the Cannabis industry that some Cannabis testing laboratories boost THC numbers to make clients happy and gain market share over other laboratories. This has led to ridiculous THC values on Cannabis product labels. Although this issue is well known, it does not ever seem to get adequately addressed. In this video, Cannabis testing veteran Jason Wilson MS explains the many ways labs can intentionally commit fraud or laboratory mistakes that lead to elevated THC values.

To see the video on YouTube, visit: https://www.youtube.com/watch?v=DUb22BP-RcM

This lecture is an excerpt from the Curious About Cannabis self-paced course on Cannabis Testing Fundamentals available for free at http://learn.cacpodcast.com

You can also learn more about Cannabis testing and quality control in labs by reading the Curious About Cannabis book available on Amazon, Barnes and Noble and other book retailers! Learn more at http://www.curiousaboutcannabisbook.com/

What’s In a Toke? Exploring the Chemistry of Cannabis Smoke and More with Dr. Riley Kirk | BTS #79

Why does smoking Cannabis deliver unique effects compared to vaping or ingesting Cannabis? Why are social media platforms banning Cannabis educators from talking about the science of Cannabis? We have questions!

In this behind-the-scenes episode I sat down with Dr. Riley Kirk (@cannabichem) from Real Isolates, the company behind the Cannabis smoke extract product called Smokenol, to talk about the chemistry of Cannabis smoke (and lots of other cool natural products science!). In this conversation we discuss some of the unique cannabinoids that show up in Cannabis smoke and what Dr. Kirk has learned during her time studying the transformations of cannabinoids like CBD.

We also discussed her struggle to share Cannabis science education with the world due to the antagonistic nature of social media toward Cannabis content. Dr. Kirk has been shadow banned and de-platformed from social media sites like Instagram and TikTok for discussing basic Cannabis science and cannabinoid pharmacology. We dive into why these issues have real-world adverse effects for anyone curious about Cannabis and what Cannabis educators should know before they rush to their Reels or Stories to talk about Cannabis.

The conversation rounds off with a dive into Dr. Kirk’s love for plants where we talk about her favorite non-Cannabis medicinal plants and the exciting things we can learn when we apply the lens of Cannabis science to other natural products.

Profound Naturals: https://www.profoundnaturals.com/

Smokenol: https://smokenol.com/

Cannabis Quality is More Than THC or Terpenes with Adie Rae PhD | BTS #78

What does Cannabis quality mean to you? Is it all about THC? Is it all about the terps?

In this behind-the-scenes episode we caught up with pharmacologist and researcher Dr. Adie Rae from Oregon, USA to talk primarily about the results of her recent publication “The Nose Knows: Aroma, but Not THC Mediates the Subjective Effects of Smoked and Vaporized Cannabis Flower” which revealed that subjective aroma enjoyment correlates more with positive Cannabis experiences than THC or terpene concentrations. We also discussed Dr. Rae’s prior and current research on the interactions between the endocannabinoid system and opioids, the need to re-evaluate how we define “quality” in the Cannabis industry, the importance of organoleptic training for medicinal herbs, and more!

Adie Rae is a neuroscientist known for her extensive expertise on cannabis. She is an Assistant Scientist at Legacy Research Institute, and adjunct faculty at Washington State University. Her human and preclinical research is focused on pain management, addiction, and harm reduction. Adie has published in top academic journals under the surname Wilson-Poe, and she is passionate about the interaction between cannabis and opioids. Adie serves as the Vice-Chair of the Oregon Cannabis Commission, and she is a long-standing member of the International Cannabinoid Research Society. Dr. Rae also co-founded the consulting and technology firm Smart Cannabis. Follow her on Instagram: @dr.adie

You can learn more about Dr. Rae and her work at https://www.smartcannabis.life/

Link to “Nose Knows” study: https://www.mdpi.com/2813-1851/1/2/8

Catching Up with Murphy Murri on Benzene, Medusa Stones, and Owning the Quality of Your Lab | BTS #75

In this behind-the-scenes episode we caught up with Murphy Murri for an extended discussion about the current state of the Cannabis industry, extraction supply chain quality issues, medusa stones, mushroom extraction and more.

Medusa stones are concentrated lumps of cannabinoids that, rather than having a clear “diamond” appearance, has a chalky appearance. And like you might expect, the “diamond” disintegrates after being handled, turning into a sticky, chalky mess. So what causes the medusa stone phenomenon in Cannabis extracts? During this conversation, Murphy breaks down the phenomenon and the controversy surrounding the hunt for the cause behind these disappointing creations.

Due to some technical difficulties on the day of recording, this discussion was recorded on Zoom instead of our usual platform, resulting in some compromised audio quality.

Sniffing Out the Skunk in Cannabis with TJ Martin of Abstrax Tech | BTS #74

In this behind-the-scenes episode we caught up with TJ Martin of Abstrax Tech to discuss their research into Cannabis extracts and the chemistry that impacts the plant’s aromas and flavors. We talk about their discovery of a family of sulfur compounds in Cannabis that are largely responsible for the skunk smell of Cannabis. We also discussed their prior research into vape pen additives and what kinds of compounds may be emitted from heated vape pen additives.

To learn more about Abstrax Tech, visit www.abstraxtech.com

Abstrax is a flavor and fragrance manufacturer that specializes in cannabis and hop raw materials, terpenes, and aroma compound research to innovate terpene driven product formulations that shape consumer packaged goods. Abstrax specializes in botanical research, ingredient manufacturing and formulation science with a specific focus on terpene research.

T.J. Martin graduated with a B.S. in Chemistry from CSU Polytechnic Pomona. He gained experience with a wide array of analytical techniques and research applications by collaborating with groups in the fields of chemistry, solid state physics, green chemistry, materials science, and polymer science. Currently T.J. is the VP of Research and Development at Abstrax where he creates custom flavor solutions and research fundamental and applied facets of cannabis science via Abstrax Labs.

Research Articles Mention in This Episode:

Identification of a New Family of Prenylated Volatile Sulfur Compounds in Cannabis Revealed by Comprehensive Two-Dimensional Gas Chromatography

Iain W. H. Oswald, Marcos A. Ojeda, Ryan J. Pobanz, Kevin A. Koby, Anthony J. Buchanan, Josh Del Rosso, Mario A. Guzman, and Thomas J. Martin. ACS Omega 2021 6 (47), 31667-31676. http://doi.org/10.1021/acsomega.1c04196

Characterization of Vaping Emission Products from Commonly Used Vape Juice Diluents
Huanhuan Jiang, C. M. Sabbir Ahmed, Thomas J. Martin, Alexa Canchola, Iain W. H. Oswald, Jose Andres Garcia, Jin Y. Chen, Kevin A. Koby, Anthony J. Buchanan, Zixu Zhao, Haofei Zhang, Kunpeng Chen, and Ying-Hsuan LinChemical Research in Toxicology 2020 33 (8), 2157-2163. http://doi.org/10.1021/acs.chemrestox.0c00174

Want a Successful Cannabis Business? Be a Crock Pot, Not a Microwave! with Alisia and Chris Ratliff | BTS #72

In this behind-the-scenes episode we join up with Alisia Ratliff once again, this time joined by her husband Chris as we catch up and learn about the work they are doing in their consulting agency, Victus Consulting Ventures. We dive into a number of topics including the science of surfactants for Cannabis products, lessons learned from years of Cannabis business consulting, issues facing Cannabis cultivators that try to scale, and more!

The takeaway? Be a crock pot, not a microwave.

Learn more about Victus Consulting Ventures at https://www.victus-cv.com/

Inspiring a Passion for Extraction Science and Technology with John MacKay, PhD | BTS #70

In this behind-the-scenes episode of The Curious About Cannabis Podcast we drop in with natural products extraction expert John MacKay, PhD. Dr. MacKay has been involved in both extraction and analytical technology for decades and has gained a lifetime of experience that he is eager to share with others. An avid educator and lifelong learner himself, Dr. MacKay teaches about Cannabis and mushroom extraction through the John MacKay Institute of Extraction Technology where he offers engaging hands-on workshops to teach the fundamentals of natural products extraction as applied to Cannabis and mushrooms. He is also a professor through several universities where he teaches about biochemistry. John is a wealth of information and has a solid sense of humor, so I hope you enjoy this conversation!

Learn more about the John MacKay Institute of Extraction Technology: https://www.extractioninstitute.com/

Learn more about Synergistic Technologies Associates: https://www.synergistictechassociates.com/

Delta-8-THC and Other Obscure Cannabinoids | Narcotica #63

Recently I spoke with Troy Farah on the podcast Narcotica all about cannabinoid science, delta-8-THC, issues around vaping and legalization, and more! Thanks to the team at Narcotica for allowing us to share this episode! I hope you enjoy! Stay curious, and take it easy.

About this Episode of Narcotica:

“Nearly half the U.S. population now have access to adult-use cannabis. Marijuana is a medicine, if it’s cultivated or extracted right, and millions of people find relief or pleasure from this fantastic plant. But as legalization accelerates, regulations have struggled to keep up. Most experts and maybe many consumers would agree that cannabis is not well regulated or could use some improvements.

Meanwhile, new cannabinoids like delta-8-THC, THC-O and more are hitting the streets, licit and illicit. This is a rapidly changing environment, which is far beyond THC and CBD, the two most well-known drugs in marijuana. It leaves a lot of questions: Are these ‘new’ cannabinoids safe? What do they do in the body? What about vaping them?

Narcotica co-host Troy Farah speaks with Jason Wilson of Medford Oregon, host of the Curious About Cannabis podcast, and author of the book of the same name, which can be found at CACpodcast.com. Jason is a biologist and science educator that has been studying the biochemistry of the cannabis plant and cannabis-derived products for nearly a decade. Jason has done work with groups like the International Institute for Cannabinoids (ICANNA) and serves as a member on the board of directors for the Oregon Cannabis Education and Resource Center.

Follow Jason on Twitter @AboutCannabis

If you liked this episode, here are others you might enjoy:
Episode 53: A Life of Getting Lit with Tommy Chong
Episode 49: Salvia: Psychedelic Oddity (Plus, Canada’s Emerging Psilocybin Scene)
Episode 25: Banning Kratom Will Escalate the Opioid Overdose Crisis with Walter Prozialeck

Producers: Christopher Moraff, Troy Farah, Zachary Siegel
Co-producer: Garrett Farah
Music: Glass Boy / Done With Fish
Intro voice: Jenny Schaye
Image: Flickr — Willpower Studios // edit: Troy Farah

Kevin Spelman PhD on Herbs to Compliment or Counteract Cannabis Effects | BTS #64

In this behind-the-scenes conversation we meet up again with molecular biologist Kevin Spelman, PhD to talk about medicinal herbs that can either compliment or counteract the effects of Cannabis in different ways. Along the way we spin out into all sorts of other topics like discussing “adaptogens”, allostatic vs. homeostatic systems in the body, issues around placebo effects and Cannabis, potential dangers concerning inhaling high concentrations of terpenes, thinking critically about drug-drug interactions with Cannabis, and more!

Learn more about Dr. Spelman’s show The Spelman Report: Phytopharmacology Review at www.thespelmanreport.com

Check out Dr. Spelman’s prior appearance on the show in Curious About Cannabis Behind-the-Scenes Episode #4: https://cacpodcast.com/bts-04-kevin-spelman-phd-on-the-endocannabinoid-system-plant-synergies-and-dietary-supplement-research/

Stay curious, and take it easy!

Codi Peterson PharmD on the Endocannabinoidome and Common Drugs, Preserving Cannabis as Medicine | BTS #63

In this behind-the-scenes episode we are joined with pharmacist Dr. Codi Peterson to talk about how modern insights into the endocannabinoid system and endocannabinoidome are affecting how pharmacists think about modern medicine.

Dr. Codi Peterson is a clinical pediatric pharmacist with diverse experiences across the pharmaceutical landscape. A Duquesne University graduate, Codi was trained in an academic teaching hospital where he learned alongside a team of healthcare professionals. Building upon general pediatric hospital experience, Codi advanced to emergency and critical care pharmacy where he found a passion for improving the pharmaceutical care of complex and dynamic patients.

Leveraging his hospital experience, Codi has had the opportunity to pursue his passion for educating others. As a staff lecturer at Orange County Emergency Medical Training, Codi teaches paramedics and firefighters the knowledge and skills they need to employ safe drug therapy in the prehospital setting. Codi has an innate ability to translate complex pharmacological information into digestible concepts that are applicable in the field. Codi also lectures to respiratory therapists and pharmacy students in the SoCal area, sharing his knowledge at every possible occasion.

Now turning his focus and skills from western medicine to a more functional and holistic therapeutic approach, Codi is enrolled at the University of Maryland School of Pharmacy where he is obtaining his MS in Medical Cannabis Science & Therapeutics. He is the President of the Medical Cannabis Student Association at UMB, an active member of the International Society of Cannabis Pharmacists, as well as the Association of Cannabinoid Specialists. With his extensive pediatric experience, Codi is poised to bring a new and needed perspective to the cannabis space. While a proponent of individual rights, home grow, and global cannabis reform, Codi also aims to defend the sanctity of medical cannabis. Codi believes cannabis IS medicine, that all patients deserve access to medicine, and that includes access to trained healthcare professionals who are able to manage complex medical patients.

You can learn more about Codi’s work in Cannabis by visiting: http://pharmdapproved.com/

Stay curious, and take it easy!

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