Remembering Raphael Mechoulam’s Legacy on Cannabis Science with Mark Scialdone, PhD | BTS 91
By cacpodcast.comIn this special episode we get together with chemist and Cannabis science educator Mark Scialdone, PhD to talk about the passing of “the godfather of Cannabis science”, Raphael Mechoulam, PhD. After his passing, many media and news outlets failed to accurately portray Mechoulam’s contributions or his place in the grand story of Cannabis science – so Dr. Scialdone and I decided to try to do our part to set the record straight. Along the way we spin off into talking about a variety of other topics like delta-8-THC synthesis from CBD, common misunderstandings around Cannabis chemistry, why the boiling point of THC is almost always incorrectly reported, and more.
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The Quest for the CB3 Receptor and Beyond with Viola Brugnatelli, PhD | BTS 89
Is there a CB3 receptor?
In this episode we catch up with Italian endocannabinoid system researcher and neuropharmacologist Viola Brugnatelli, PhD to discuss her work investigating the activity of orphaned G-protein coupled receptors (GPCRs) like GPR55, GPR18, GPR92, and others.
We also discuss Viola’s decision to focus her energy on educating the healthcare community and others about the science of Cannabis through her company Cannabiscientia which just published a great resource for health care providers called The Principles of Clinical Cannabinology.
To learn more about Cannabiscientia, visit https://cannabiscientia.com/
#cannabis #cannabinoids #cb3 #ecs #endocannabinoidsystem #cannabiscientia #cannabisscience #cannabinoidpharmacology #medicalcannabis #medicalmarijuana #curiousaboutcannabis
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Cannabis and the Convergence of Neurodivergence with Miyabe Shields PhD | BTS 87
Disclaimer: In this episode, we discuss some heavy topics that touch on mental health struggles and suicidal ideation. None of the information in this episode or any other Curious About Cannabis episode should be considered medical advice. All of our content is for educational and entertainment purposes only.
In this raw behind-the-scenes episode I had the chance to catch up with endocannabinoid system researcher and science communicator Miyabe Shields, PhD. We spent much of our time together discussing the convergence of Cannabis, mental health, and neurodivergence – addressing many of the taboos and social stigmas associated with altering consciousness and treating the mind with Cannabis.
This is almost certainly just the beginning of a series of conversations that Miyabe and I will be having as we continue to unpack their fascination with the endocannabinoid system and natural products science – so stay tuned for more!
#Cannabis #CannabisResearch #Neurodiversity #Neurodivergent #Spectrum #Consciousness #CannabisEducation #MedicalCannabis #CannabisForMentalHealth #Psychology #NaturalProducts #CuriousAboutCannabis
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CBD, Pain and Opioids: Bringing Translational Research to Cannabis with Maria T Rivera-Garcia PhD | BTS 86
In this behind-the-scenes interview we talk with Dr. Maria T Rivera-Garcia about her research investigating the effects of CBD-rich whole plant extract vapor on pain and opioid reward seeking behavior in female rats in a study titled, “High-CBD Cannabis Vapor Attenuates Opioid Reward and Partially Modulates Nociception in Female Rats”.
While on the surface this may seem like a simple study about how CBD influences opioid use – there is actually a lot more going on here. First of all this study utilized female rodents, which is very uncommon. The vast majority of preclinical rodent research uses male rodents almost exclusively due to reasons we unpack during the episode. This has led to a gross under-representation of sex differences in biomedical research.
Second, Maria and colleagues decided to utilize the vapor of whole plant CBD-rich Cannabis extract rather than using CBD isolate that is often diluted and injected, ultimately leading to results that do not accurately reflect real-world situations.
Together, these two decisions point to a common theme that is woven into this research study – scientists need to focus on doing research that better represents the real world. The results from this study are fascinating, so get your notebook ready and let’s dive in!
Link to the study: https://www.sciencedirect.com/science/article/pii/S2772392522000451
About Maria:
Maria Teresa Rivera-Garcia has a major in psychology and a minor in neuroscience from the National Autonomous University of Mexico, where she started defining her academic interests towards the study of neurobiological mechanisms of addiction. After undergrad, Maria did a Master and a PhD in Neuropharmacology and Experimental Therapeutics, her research focused on the neurochemical effects of solvent inhalation and its relation with the development of psychosis. Maria moved to the US in 2016 to pursue her postdoctoral training in the Oregon and Health and Science University, studying sex and age differences in dopaminergic function and how this is related to psychiatric illnesses, including addiction. In 2020, Maria joined Legacy Research Institute to complete her second postdoctoral stay under the guidance of Dr. Adie R. Wilson-Poe, where she studied the pharmacological interaction between opioids and cannabinoids in pain-oriented models. Recently, Maria got accredited as Qualified Mental Health Provider and became a member of the Cascadia Health clinicians team, currently providing services within the Child and Family Program.
#CannabisEducation #CBD #CBDOil #WholePlantExtract #WholePlant #FullSpectrum #BroadSpectrum #Hemp #HempExtract #MedicalCannabis #Addiction #MentalHealth #Opioids #CuriousAboutCannabis
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Standards: The Final Frontier? ASTM Intl’s Effort to Standardize the Cannabis Industry with Darwin Millard (The Spock of Cannabis) | BTS 83
In this behind-the-scenes conversation I beam aboard the USS Cannabis starship to join “The Spock of Cannabis” Darwin Millard to talk about ASTM International’s efforts to bring the planet together to develop unifying standards for the Cannabis industry. In this conversation we talk about why the development of international quality standards is critical, how ASTM’s collaborative open-door process of standard development is unique compared to how other organizations or government agencies develop standards, and how everyone with any interest in Cannabis has been invited to join the table to lend a voice and help drive the future of the international Cannabis industry.
You can learn more about ASTM International’s Cannabis subcommittee and get involved here: https://www.astm.org/get-involved/technical-committees/committee-d37
You can learn more about Darwin’s work at thespockofcannabis.com
“Live Long and Process!” – The Spock of Cannabis
#CannabisEducation #CannabisQuality #Cannabis #Hemp #CannabisIndustry #HempEducation #GlobalCannabis #GlobalCannabisIndustry #ASTM #ASTMIntl #LiveLongAndProcess #CuriousAboutCannabis
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Cannabinoid Science: Past, Present and Future (Southern Oregon University Lecture, 2021)
The history of cannabinoid science tells a fascinating story that many people are really unfamiliar with. In this lecture, which I gave for Southern Oregon University back in October of 2021, I chart some of the basic series of events that led to the discovery of CBD, THC, cannabinoid receptors, the endocannabinoid system, and the endocannabinoidome.
The video associated with this lecture is available on the Curious About Cannabis YouTube at http://www.youtube.com/@curiousaboutcannabis
The 2023 Curious About Cannabis Master Class is coming up! Spend 6 months diving into a Cannabis science crash course with me and over a dozen special guests! Register today at http://www.masterclasscannabis.com
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Critical Cannabis Genetics Questions with Reggie Gaudino PhD (From 2022 Master Class)
In this episode I wanted to share a presentation given by Reggie Gaudino PhD from the 2022 Curious About Cannabis Master Class where Reggie spent over an hour and a half diving into some of the most pressing questions people often have about Cannabis genetics.
Reggie will be joining us once again for our 2023 Curious About Cannabis Master Class along with over a dozen other special guests comprised of renowned researchers, clinicians and industry professionals ready to share their passion for Cannabis education with you! Class starts on March 23rd and runs through August 24th, 2023!
Learn more about the CAC Master Class at www.masterclasscannabis.com or visit www.cacpodcast.com/events to learn more about CAC events.
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How Do Testing Labs Boost THC Numbers? | Lecture by Jason Wilson MS
45% THC Flower?!
It is a well known issue in the Cannabis industry that some Cannabis testing laboratories boost THC numbers to make clients happy and gain market share over other laboratories. This has led to ridiculous THC values on Cannabis product labels. Although this issue is well known, it does not ever seem to get adequately addressed. In this video, Cannabis testing veteran Jason Wilson MS explains the many ways labs can intentionally commit fraud or laboratory mistakes that lead to elevated THC values.
To see the video on YouTube, visit: https://www.youtube.com/watch?v=DUb22BP-RcM
This lecture is an excerpt from the Curious About Cannabis self-paced course on Cannabis Testing Fundamentals available for free at http://learn.cacpodcast.com
You can also learn more about Cannabis testing and quality control in labs by reading the Curious About Cannabis book available on Amazon, Barnes and Noble and other book retailers! Learn more at http://www.curiousaboutcannabisbook.com/
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What’s In a Toke? Exploring the Chemistry of Cannabis Smoke and More with Dr. Riley Kirk | BTS #79
Why does smoking Cannabis deliver unique effects compared to vaping or ingesting Cannabis? Why are social media platforms banning Cannabis educators from talking about the science of Cannabis? We have questions!
In this behind-the-scenes episode I sat down with Dr. Riley Kirk (@cannabichem) from Real Isolates, the company behind the Cannabis smoke extract product called Smokenol, to talk about the chemistry of Cannabis smoke (and lots of other cool natural products science!). In this conversation we discuss some of the unique cannabinoids that show up in Cannabis smoke and what Dr. Kirk has learned during her time studying the transformations of cannabinoids like CBD.
We also discussed her struggle to share Cannabis science education with the world due to the antagonistic nature of social media toward Cannabis content. Dr. Kirk has been shadow banned and de-platformed from social media sites like Instagram and TikTok for discussing basic Cannabis science and cannabinoid pharmacology. We dive into why these issues have real-world adverse effects for anyone curious about Cannabis and what Cannabis educators should know before they rush to their Reels or Stories to talk about Cannabis.
The conversation rounds off with a dive into Dr. Kirk’s love for plants where we talk about her favorite non-Cannabis medicinal plants and the exciting things we can learn when we apply the lens of Cannabis science to other natural products.
Profound Naturals: https://www.profoundnaturals.com/
Smokenol: https://smokenol.com/
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Cannabis Quality is More Than THC or Terpenes with Adie Rae PhD | BTS #78
What does Cannabis quality mean to you? Is it all about THC? Is it all about the terps?
In this behind-the-scenes episode we caught up with pharmacologist and researcher Dr. Adie Rae from Oregon, USA to talk primarily about the results of her recent publication “The Nose Knows: Aroma, but Not THC Mediates the Subjective Effects of Smoked and Vaporized Cannabis Flower” which revealed that subjective aroma enjoyment correlates more with positive Cannabis experiences than THC or terpene concentrations. We also discussed Dr. Rae’s prior and current research on the interactions between the endocannabinoid system and opioids, the need to re-evaluate how we define “quality” in the Cannabis industry, the importance of organoleptic training for medicinal herbs, and more!
Adie Rae is a neuroscientist known for her extensive expertise on cannabis. She is an Assistant Scientist at Legacy Research Institute, and adjunct faculty at Washington State University. Her human and preclinical research is focused on pain management, addiction, and harm reduction. Adie has published in top academic journals under the surname Wilson-Poe, and she is passionate about the interaction between cannabis and opioids. Adie serves as the Vice-Chair of the Oregon Cannabis Commission, and she is a long-standing member of the International Cannabinoid Research Society. Dr. Rae also co-founded the consulting and technology firm Smart Cannabis. Follow her on Instagram: @dr.adie
You can learn more about Dr. Rae and her work at https://www.smartcannabis.life/
Link to “Nose Knows” study: https://www.mdpi.com/2813-1851/1/2/8
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